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Individual trials were analyzed for their quality using the Cochrane Collaborations tool for assessing the risk of bias in randomized trials ( Figure S1 ) ( Statistical Analysis The pooled estimates of the weighted mean differences (WMDs) and 95% CIs for continuous outcomes, including the changes in HbA1c and FPG, as well as the pooled risk ratios (RRs) and their 95% CIs for dichotomous outcomes, including the proportion of participants achieving target HbA1c values and the risk of hypoglycemia, were calculated

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is supported by the Italian Ministry of University Research grant 20229ZA2YF

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S001155 Supplier G-Biosciences Supplier No

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